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Issue 16, 1997
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Synthesis of L-selenocystine,L-[77Se]selenocystine andL-tellurocystine


Synthetic routes for the synthesis of stable isotope labelled amino acids which contain either a selenium or a tellurium atom have been explored. L-Selenocystine, L-[77Se]selenocystine and L-tellurocystine have been constructed in four steps from commercially available methyl (2S)-2-[(tert-butoxycarbonyl)amino]-3- hydroxypropionate. The sequence of reactions has been successfully scaled up giving significant quantities of the chalcogen based amino acids in fair to good overall yield.

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Article type: Paper
DOI: 10.1039/A600180G
J. Chem. Soc., Perkin Trans. 1, 1997, 2443-2448

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    Synthesis of L-selenocystine, L-[77Se]selenocystine and L-tellurocystine

    E. M. Stocking, J. N. Schwarz, H. Senn, M. Salzmann and L. A. Silks, J. Chem. Soc., Perkin Trans. 1, 1997, 2443
    DOI: 10.1039/A600180G

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