One-pot Synthesis of 1,2,3,4-Tetrafluoroacridines from pentafluorobenzaldehyde1

Abstract

1,2,3,4-Tetrafluoroacridines (accompanied in certain cases by their 3-arylamino derivatives) have been prepared in one-pot fashion (via formation in situ of the corresponding Schiff bases) by heating pentafluorobenzaldehyde with a 2 molar equivalence of aniline, para-substituted anilines 4-RC ₆ H ₄ NH ₂ (R=OMe, Me, Bu ^t , F, Cl, Br) or 3,5-dimethylaniline in boiling o-dichlorobenzene.