Total synthesis of carbocyclic nikkomycin C
Abstract
The carbocyclic analogue 11 of nikkomycin C 1 is prepared by a sequence involving allylic rearrangement of the imino ester adduct 3, palladium-mediated substitution of the allylic lactone 4c with uracil bis(trimethylsilyl)ether 6, and osmylation of the double bond.