The hydrogenation of methyl acetoacetate to give optically pure methyl 3-hydroxybutyrate is performed hetero-geneously with high activity and enantioselectivity under mild reaction conditions due to the combination of Brønsted acid and Ru–binap sites in a polydimethylsiloxane membrane matrix.
D. Tas, C. Thoelen, I. F. J. Vankelecom and P. A. Jacobs, Chem. Commun., 1997, 2323 DOI: 10.1039/A705604D
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