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Issue 6, 1997
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Regio- and enantio-selective allylic alkylation catalysed by a chiral monophosphine–palladium complex

Abstract

Allylic alkylation of racemic 1-arylprop-2-enyl acetates [ArCH(OAc)CH[double bond, length as m-dash]CH 2 ] with the sodium enolate of dimethyl methylmalonate in the presence of a palladium catalyst coordinated with (R)-2-diphenylphosphino-2′-methoxy-1,1′-binaphthyl [(R)-MeO-MOP] proceeds with high branch selectivity (90%) to give chiral products [ArC*H(Nu)CH[double bond, length as m-dash]CH 2 ] of up to 87% ee.

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Article information


Chem. Commun., 1997, 561-562
Article type
Paper

Regio- and enantio-selective allylic alkylation catalysed by a chiral monophosphine–palladium complex

T. Hayashi, M. Kawatsura and Y. Uozumi, Chem. Commun., 1997, 561
DOI: 10.1039/A700045F

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