Podocarpane-to-spongian skeleton conversion. Synthesis of (+)-isoagatholactone and (–)-spongia-13(16),14-diene
Abstract
A stereoselective synthesis of the spongian diterpenes (+)-isoagatholactone 5 and (–)-spongia-13(16),14-diene 6 is achieved starting from (+)-podocarp-8(14)-en-13-one 3 (R = H)via the common intermediate β-hydroxy ketone 13.