Transformations of isoxazolidine and dihydropyran derivatives to optically active compounds
Abstract
Isoxazolidine and dihydropyran spiro derivatives can be easily transformed, by hydrolysis and hydrogenolysis, to give δ-keto esters, δ-keto acids, β-amino esters, β-amino acids and 3-amino alcohols in good yields. Startiing from optically active compounds enantiomerically pure products are obtained. In some cases, reactions were induced by microwave irradiation.