A stereospecific synthesis of carbocyclic NAD+ incorporating a methylenebisphosphonatelinkage in place of the natural pyrophosphate gives an analogue 4 of the natural coenzyme NAD+ 3a designed to act as an inhibitor of ADP-ribosyl cyclase and to resist non-specific phosphatase degradation.
E. J. Hutchinson, B. F. Taylor and G. M. Blackburn, Chem. Commun., 1996, 2765 DOI: 10.1039/CC9960002765
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