The copper(I) catalysed aldol reaction between methyl isocyanoacetate and (S)-3-fluoro-1-(4-methylphenyl)-sulfinylacetone affords oxazoline products which, after diastereoisomer separation, give in high yields optically pure 3-fluoromethylthreonine analogues whose absolute and relative configurations have been assigned through X-ray analyses.
A. Arnone, D. Gestmann, S. V. Meille, G. Resnati and G. Sidoti, Chem. Commun., 1996, 2569 DOI: 10.1039/CC9960002569
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