Relationship between binding affinity for calf-thymus DNA of [Pt(2,2′-bpy)(n-Rpy)2]2+(n= 2,4) and basicity of coordinated pyridine
Abstract
The binding affinity for DNA of the complexes [Pt(2,2′-bpy)(n-Rpy)2]2+(n= 2,4) systematically increases on increasing pKa of the coordinated pyridine, with the exception of the 2-methyl-substituted derivative.
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