An indole-terminated tris(macrocyclic) compound, designed to be a channel-former, is an effective carrier in bluk membranes but fails to function in a lipid bilayer owing to hydrogen bond formation which blocks the channel.
O. Murillo, E. Abel, G. E. M. Maguire and G. W. Gokel, Chem. Commun., 1996, 2147 DOI: 10.1039/CC9960002147
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