Photoactivated thiazole-based DNA-cleaving agents: dramatic change of recognition sequence depending on the number of thiazole units
Abstract
By increasing the number of thiazole units in the photoactive DNA cleaving compounds, 4-(3-dimethylsulfoniopropyl-aminocarbonyl)-2-[2-(4-nitrobenzoylamino)ethyl] oligo- thiazole, from one or two to three, the specificity of their DNA cleavage was dramatically altered from 5′-AAATN-3′(N ≠ G) to 5′-GG-3′.