Issue 15, 1996

Synthesis of phosphorofluoridate analogues of myo-inositol 1,4,5,-tris(phosphate) and their biological activity

Abstract

Phosphorofluoridate analogues, of myo-inositol 1,4,5-tris(phosphate), 4-and 5-phosphorofluoridate and 4,5-bis(phosphorofluoridate), were prepared and their biological acivity towards InsP3 5-phosphatase was found to be similar to or more activ than that for InsP3 while they proved to be less active in the binding assay than InsP3.

Article information

Article type
Paper

Chem. Commun., 1996, 1815-1816

Synthesis of phosphorofluoridate analogues of myo-inositol 1,4,5,-tris(phosphate) and their biological activity

Y. Watanabe, S. Sofue, S. Ozaki and M. Hirata, Chem. Commun., 1996, 1815 DOI: 10.1039/CC9960001815

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