An expedient synthesis of (α,α-difluoroprop-2-ynyl)phosphonate esters
Abstract
Pfitzner–Moffatt oxidation of diethyl α-hydroxyalkyne-phosphonate 4, prepared by nucleophilic attack of diethyl phosphite on the corresponding aldehyde, followed by DAST fluorination of the resulting α-ketophosphonate 8, results in the smooth formation of α,α-difluoroalkynephosphonate 7.