Highly diastereoselective synthesis of octahydroacridines by domino imine condensation–intramolecular polar [4π++ 2π]-cycloaddition of anilines and ω-unsaturated aldehydes
Abstract
Substituted 1,2,3,4,4a,9,9a,10-octahydroacridines with five stereogenic centres are formed highly diastereoselectively by the domino imine condensation–intramolecular polar [4π++ 2π]-cycloaddition of anilines and ω-unsaturated aldehydes.