Replacement of the Gln7 residue, which is well conserved among ion-channel-forming peptaibols, by an Ala in trichosporin-B-Vla (TS-B-Vla = AcUAUAUUQUIUGLUPVUUQQPheol; U =α-aminoisobutyric acid, Pheol = phenylalaninol) alters neither the multilevel nature of the TS-B-Via channel nor its conductance, but abolished the rectification of the membrane current characteristic of the TS-B-Vla channel.
Y. Nagaoka, A. Iida, T. Kambara, K. Asami and T. Fujita, Chem. Commun., 1996, 1079 DOI: 10.1039/CC9960001079
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