Benzyne addition to N-alkyl-4-hydroxy-1-methylisoquinolinium salts; a new and convenient synthesis of (±)-5-methyl-10,11-dihydro-5H-dibenzo-[a,d]cyclohepten-5,10-imine (MK801)
Abstract
Addition to benzyne, generated by three different methods, to N-benzyl-4-hydroxy-1-methylisoquinolinium betaine provides N-benzyl-5-methyl-11-oxo-5Hdibenzo[a,d] cyclohepten-5,10-imine which can be converted to MK801.