Preparation of some new anomeric carbohydrate difluoromethylenephosphonates via phosphonyl radical addition to gem-difluoroenol ethers
Abstract
Generation of a phosphonyl radical either from diethyl phosphite, or diethyl (phenylselenyl)phosphonate in conjunction with tributylstannane, in the presence of a carbohydrate gem-difluoroenol ether provides a new route to anomeric difluoromethylenephosphonates; in the course of these reactions, some unusual stereochemical effects are observed.