Catalytic hydroxylation of phenylcyclohexane 1 by wild-type and the Y96A and Y96F mutant forms of cytochrome P450cam occurs only at the 3- and 4-positions on the cyclohexane ring, giving cis-3-phenylcyclohexanol 2, cis-4-phenylcyclohexanol 3 and trans-4-phenylcyclohexanol 4.
P. A. England, D. A. Rouch, A. C. G. Westlake, S. G. Bell, D. P. Nickerson, M. Webberley, S. L. Flitsch and L. Wong, Chem. Commun., 1996, 357 DOI: 10.1039/CC9960000357
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