Catalysis of DNA cleavage by lanthanide complexes with nucleophilic or intercalating ligands and their kinetic characterization
Abstract
The catalysis of plasmid ds-DNA cleavage by lanthanoid cations and their complexes is characterized by saturation kinetics; addition of polyamines or cryptand does not hinder catalysis, which can be enhanced to a total factor of 107 by alcoholic co-substrates such as glycerol, or by intercalating ligands.