β-Phosphorylated α-phenyl-N-tert-butylnitrone (PBN) analogues: a new series of spin traps for oxyl radicals

Abstract

The two β-phosphorylated nitrones, N-benzylidene-1-diethoxyphosphoryl-1-methylethylamine N-oxide 3(PPN) and 1-diethoxyphosphoryl-1-methyl-N-[(1-oxidopyridin-1-ium-4-yl)methylidene]ethylamine N-oxide 4 (4-PyOPN), which are the phosphorylated analogues of α-phenyl-N-tert-butylnitrone (PBN) and α-(1-oxidopyridin-1-ium-4-yl)-N-tert-butylnitrone (4-PyOBN), respectively, have been prepared and their ability to trap oxygen-centred radicals has been investigated.