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Issue 1, 1995
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Ligands which bind weakly to vancomycin: studies by 13C NMR spectroscopy

Abstract

13 C NMR chemical shifts of vancomycin have been used to obtain the association constants for a number of ligands which bind weakly to the antibiotic. The change in these 13C chemical shifts upon stepwise addition of ligands provides evidence that the ligands bind in a manner analogous to natural cell-wall precursor analogues. The binding constants obtained are in good agreement with those determined earlier by other methods. Where the ligands are amino acids (glycine or alanine), a potential alkylammonium to amide carbonyl interaction does not promote binding.

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Article information


J. Chem. Soc., Perkin Trans. 2, 1995, 159-162
Article type
Paper

Ligands which bind weakly to vancomycin: studies by 13C NMR spectroscopy

C. M. Pearce, U. Gerhard and D. H. Williams, J. Chem. Soc., Perkin Trans. 2, 1995, 159
DOI: 10.1039/P29950000159

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