(Z)-Heptadec-8-enylboronic acid: a potential lipase inhibitor
Abstract
(Z)-Heptadec-8-enylboronic acid, a potential lipase inhibitor that is isosteric with oleic acid, and that is unexpectedly sensitive to aerial oxidation, has been prepared in 23% overall yield from dec-1-yne and 7-bromoheptanol. Disappointingly, the target compound proved inactive under conditions where lipase inhibition would have been expected.