Reaction of N-arylsulfonylaziridines with dimethylsulfoniumethoxycarbonyl methylide: regio- and stereo-selective synthesis of 1-arylsulfonyl-2-ethoxycarbonyl azetidines
Abstract
Synthesis and characterization of 4-aryl-, 3,4-diaryl- and 3-alkyl-4-aryl-N-arylsuIfonylazetidines, bearing a 2-ethoxycarbonyl group are described. The methodology used involves transfer of an ethoxycarbonyl substituted methylene group from dimethylsulfoniumethoxycarbonyl methylide to N-arylsulfonylaziridines. The synthesis is both regio- and stereo-selective.