Parasite glycoconjugates. Part 4. Chemical synthesis of disaccharide and phosphorylated oligosaccharide fragments of Leishmania donovani antigenic lipophosphoglycan

Abstract

The disaccharide 1, tetraglycosyl monophosphate 2, hexaglycosyl diphosphate 3 and octaglycosyl triphosphate 4, which are fragments of the phosphoglycan portion of Leishmania donovani lipohosphoglycan, have been synthesized. Elongation of the chain was performed using the suitably protected glycobiosyl hydrogenphosphonate derivatives 5 and 6 for the successive introduction of glycobiosyl phosphate units.