Synthesis based on cyclohexadienes. Part 17. Total synthesis of the sesquiterpenes of Eremophila georgei diels
The first stereoselective total synthesis of the novel sesquiterpenes 1 and 2 is described. The preparation of the key intermediate 27 involved a rearrangement of a bicyclo[3.2.1]octane framework to an isomeric bicyclo[3.2.1]octene skeleton via a bicyclo[2.2.2]octane derivative.