Three sugar derivatives (6, 7 and 13) of the antimitotic agent combretastatin A-4 1 have been synthesized. Two of these water-soluble derivatives (6, 13) showed strong cytotoxicity to the murine P388 cell line.
R. T. Brown, B. W. Fox, J. A. Hadfield, A. T. McGown, S. P. Mayalarp, G. R. Pettit and J. A. Woods, J. Chem. Soc., Perkin Trans. 1, 1995, 577 DOI: 10.1039/P19950000577
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