Stereo- and enantio-controlled synthesis of (+)-juvabione and (+)-epijuvabione from (+)-norcamphor
Abstract
(+)-Juvabione and (+)-epijuvabione, natural sesquiterpenes exhibiting insect juvenile hormone activity, have been synthesized with complete stereo- and enantio-control using (+)-norcamphor as the chiral precursor via both the enantiomeric bicyclo[3.2.1]octenone intermediates.