A new base promoted isomerisation of 6-(1,1-dimethylethoxy)-2H-pyran-3-one to 4-(1,1-dimethylethoxy)-5-hydroxy-2-cyclopentenone is used in the preparation of 2-bromo-5-[(1,1-dimethylethyl)dimethylsilyloxy]-4-hydroxy-2-cyclopentenone, a potential intermediate for use in the synthesis of Neocarzinostatin and Kedarcidin chromophores.
S. Caddick and S. Khan, J. Chem. Soc., Chem. Commun., 1995, 1971 DOI: 10.1039/C39950001971
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