An efficient synthesis of the cannabinoid antagonist SR141716A is presented and the structure is established by nOe experiments; tritiated SR141716A is synthesized by a novel sequence of metallation–iodination–tritiation and the labelled site is shown by tritium NMR and tritium–hydrogen nOe experiments.
H. H. Seltzman, F. I. Carroll, J. P. Burgess, C. D. Wyrick and D. F. Burch, J. Chem. Soc., Chem. Commun., 1995, 1549 DOI: 10.1039/C39950001549
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