Facile synthesis of protected C-terminal peptide segments by Fmoc/But solid-phase procedures on N-Fmoc-9-amino-xanthen-3-yloxymethyl polystyrene resin
Abstract
Side-chain protected peptidyl amides, peptidyl tert-butyl esters, and the novel peptidyl 4-[N-(oxyacetyl)-β-alaninamide]-benzyl ester (HMP-β-Ala-NH2 ester) have been synthesised in excellent yields on N-Fmoc-9-amino-xanthen-3-yloxymethyl polystyrene resin and selectively cleaved from the solid support using 1% trifluoroacctic acid in dichloromethane within 7–8 min.