The nucleotide analogue 5 has been synthesized, via formation of the diol 11, and has been shown to be inactive against HSV in vitro. Resolution of the intermediate diol 11 was effected using a highly stereoselective enzyme-catalysed acetylation.
D. M. Coe, A. Garofalo, S. M. Roberts, R. Storer and A. J. Thorpe, J. Chem. Soc., Perkin Trans. 1, 1994, 3061 DOI: 10.1039/P19940003061
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