A simple and efficient way to substituted 3-halogenopyruvamides from substituted α-carbamoyl-α-cyanooxiranes
Abstract
Regioselective ring opening of the readily accessible α-carbamoyl-α-cyanooxiranes with hydrogen halides gives β-halogeno-α-cyanohydrins which on being decyanated give, quantitatively, the corresponding substituted 3-halogenopyruvamides.