Synthesis of functionalized compounds containing a difluoromethylene moiety
Abstract
By a two-step sequence, functionalized CF2-containing compounds have been readily synthesized from CF2Br2. In the presence of CrCl3/Fe, CF2Br2 added to both electron-deficient and electron-rich alkenes to give CF2Br-containing compounds. Promoted by CoIII/Zn, these adducts reacted further with a further molecule of alkene to give various CF2-containing compounds in good yields.