Concise and practical approach to chiral des-A B-trienic corticosteroids
Abstract
A concise and practical route to the enantiomerically pure des-A B-trienic steroid 14 was developed by thermolysis of the optically active alkenic benzocyclobutene 13 obtained by selective nucleophilic addition of isopropenyl group to the chiral epoxide 9 as a key step.