Synthesis of enantiomerically pure bicyclo[3.1.0]hexanes from D-ribose by intramolecular cyclopropanation
Abstract
Highly functionalized optically pure bicyclo[3.1.0]hexan-2-ones 6a and 6b are easily obtained by the Intramolecular cyclopropanation of a D-ribose derivative using the iodonium ylide or diazo compound methods, which afford the final products with opposite diastereoselectivities.