Convenient procedure for the reduction of β-enamino ketones: synthesis of γ-amino alcohols and tetrahydro-1,3-oxazines
Abstract
γ-Amino alcohols 3 can be easily synthesized in very good yields by reduction of enaminones 1 with Na in Pr1OH–tetrahydrofuran. The reaction is fast, easy to perform, inexpensive and the easily accessible starting materials provide a convenient entry to γ-amino alcohols. The relative configuration assignment of the diastereoisomeric γ-amino alcohols obtained has been established by 1H and 13C NMR studies and unequivocally assigned by their cyclic tetrahydro-1,3-oxazine derivatives 4.