Fluorination of 5′-deoxy-5′-(methylthio)adenosine with xenon difluoride provides an expedient synthesis of (fluoromethylthio)adenosine
Abstract
Fluorination of 5′-deoxy-5′-(fluoromethylthio)adenosine derivatives with xenon difluoride at –60 °C in dichloromethane occurs exclusively at the methylthio position to provide a simple and efficient preparation of 5′-deoxy-5′-(fluoromethylthio)adenosine.