Rearrangement of 2-(arylmethoxy)methyl-2-oxazolines via lithium azaenolates: a facile synthetic route of ortho-methylmandelic acid derivatives
Abstract
2-(Arylmethoxy)methyl-2-oxazolines, on treatment with LDA in THF at low temperature, rearrange to afford products which are hydrolysed to ortho-methylmandelic acids or α-(1-methyl-2-naphthyl)glycolic acid.