The Nim-2-adamantyloxycarbonyl (2-Adoc) group is suitable for the protection of the imidazole function of the histidine residue in peptide synthesis in terms of its stability to trifluoroacetic acid (TFA), tertiary amines and 1-hydroxybenzotriazole (HOBt), and its reduction of racemization rate during the coupling reaction.
Y. Nishiyama, N. Shintomi, Y. Kondo and Y. Okada, J. Chem. Soc., Chem. Commun., 1994, 2515 DOI: 10.1039/C39940002515
To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.
If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.
If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.
Read more about how to correctly acknowledge RSC content.
Please wait while we load your content...