Synthesis of the A/E/F tricyclic section of the norditerpenoid alkaloid methyllycaconitine, a potent inhibitor of neurotransmission
Abstract
The tricyclic amine (±)-2; R = H, with five stereogenic centres, representing the A/E/F ring system of the norditerpene alkaloid methyllycaconitine, is synthesised from penta-1,4-dien-3-ol in nine steps, with overall yield 16%.