The stability of duplex DNA containing 3,N4-etheno-2′-deoxycytidine (εdC). A UV melting and high resolution 1H NMR study
Abstract
The mutagenic lesion 3,N4-etheno-2′-deoxycytidine (εdC) greatly destabilises DNA when paired with each of the natural bases although the solution structure of a duplex containing a εC : A pair shows that the lesion does not greatly disrupt base pairing in the duplex.