Successive diarylation at the carbon positions (2/4 and 2/5) of 1H-imidazole and its application to the total synthesis of nortopsentin D
Abstract
Nortopsentin D, an antifungal 2,4-diinodolylimidazole, is synthesized by use of a successive and regioselective diarylation, in which N-protected 2,4,5-tri- and 4,5-di-bromoimidazole derivatives are treated with N-silylated 3-indolylboric acid in the presence of a palladium(o) catalyst.