SCHEDULED MAINTENANCE
Two trace (0.7 and 2.2 × 10–7% yields) potent antineoplastic macrocyclic lactones termed spongistatins 8 (2a) and 9 (2b) have been isolated from the African marine sponge Spirastrella spinispirulifera and found to be very potent inhibitors of glutamate-induced tubulin polymerization.
G. R. Pettit, Z. A. Cichacz, C. L. Herald, F. Gao, M. R. Boyd, J. M. Schmidt, E. Hamel and R. Bai, J. Chem. Soc., Chem. Commun., 1994, 1605 DOI: 10.1039/C39940001605
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