Probing the D-1,4,5-IP3/D-1,3,4,5-IP4 functional interface. Synthesis and pharmacology of novel D-3-modified myo-inositol trisphosphate analogues

Abstract

To explore the biological significance of the _D-3 position phosphorylation of the second messenger _D-myo-inositol 1,4,5-trisphosphate (IP₃) in cellular signalling, three novel _D-3-substituted analogues of IP₃ have been synthesized; their binding and Ca²⁺-release profiles at the IP₃-receptor have been studied and shown to correlate with the steric requirement of the _D-3 substituent.