Synthesis of L-O-phosphohomoserine and its C-3 chirally deuteriated isotopomers: probes for the pyridoxal phosphate dependent threonine synthase reaction
Abstract
A short efficient synthesis of the threonine synthase substrate L-O-phosphohomoserine and its C-3 chirally deuteriated isotopomers is described; the route also provides access to L-homoserine and its C-3 chirally deuteriated isotopomers in high yield.