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Issue 5, 1994
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1D-myo-inositol 1,4,5-trisphosphate and 1D-myo-inositol 1,3,4,5-tetrakisphosphate analogues modified at C-3; synthesis of 1D-3-C-(trifluoromethyl)-myo-inositol 1,4,5-trisphosphate and 1L-chiro-insitol 1,2,3,5-tetrakisphosphate from L-quebrachitol

Abstract

The novel 3-modified 1D-myo-inositol 1,4,5-trisphosphate [Ins(1,4,5)P3] analogues 1D-3-C-(trifluoromethyl)-myo-inositol 1,4,5-trisphosphate and 1L-chiro-inositol 1,2,3,5-tetrakisphosphate are synthesized from L-quebrachitol, and the preliminary results on their Ca2+ releasing activity suggest that the Ins(1,4,5)P3 receptor can accommodate some steric bulk in the axial region of the 3-position of Ins(1,4,5)P3 when the equatorial 3-hydroxy group is retained.

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Article type: Paper
DOI: 10.1039/C39940000599
Citation: J. Chem. Soc., Chem. Commun., 1994,0, 599-600

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    1D-myo-inositol 1,4,5-trisphosphate and 1D-myo-inositol 1,3,4,5-tetrakisphosphate analogues modified at C-3; synthesis of 1D-3-C-(trifluoromethyl)-myo-inositol 1,4,5-trisphosphate and 1L-chiro-insitol 1,2,3,5-tetrakisphosphate from L-quebrachitol

    A. P. Kozikowski, V. I. Ognyanov, A. H. Fauq, R. A. Wilcox and S. R. Nahorski, J. Chem. Soc., Chem. Commun., 1994, 0, 599
    DOI: 10.1039/C39940000599

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