1-Naphth-1-ylethanol 1 of 92% enantiomeric excess (e.e.) can be raised to 99.6% e.e. in an overall yield of 78% by attaching it to oxalyl chloride, separating the lk diester from the ul by crystallisation, and hydrolysing the diester; the method is potentially general for functional molecules that can easily be attached to and then taken off a bifunctional reagent.
I. Fleming and S. K. Ghosh, J. Chem. Soc., Chem. Commun., 1994, 99 DOI: 10.1039/C39940000099
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