Quantification of tiaprofenic acid using voltammetric and spectrophotometric techniques

Abstract

Two methods for the determination of tiaprofenic acid (Surgam) are described. Direct current polarography and cyclic voltammetry were used to study the reduction behaviour of tiaprofenic acid, whereas direct current stripping voltammetry was applied to the quantitative measurement of the drug in dosage form and in biological media. The spectrophotometric method depends on the determination of the drug after extraction as an ion-association complex with Safranine-T in chloroform at pH 7.4.