Synthesis of 3-octyl-, 3-cyclohexylmethyl- and 3-carboxy-3-(prop-2-ynyl)pyrrolidine-2,5-diones required as potential aromatase inhibitors
Abstract
Routes are described for the synthesis of 3-alkyl-3-(prop-2-ynyl)pyrrolidine-2,5-diones 5 and 6, which are not available by the literature method for the corresponding prop-2-enyl analogues, and 3-carboxy-3-(prop-2-ynyl)pyrrolidine-2,5-dione 7.