Issue 21, 1993

Synthesis of 3-octyl-, 3-cyclohexylmethyl- and 3-carboxy-3-(prop-2-ynyl)pyrrolidine-2,5-diones required as potential aromatase inhibitors

Abstract

Routes are described for the synthesis of 3-alkyl-3-(prop-2-ynyl)pyrrolidine-2,5-diones 5 and 6, which are not available by the literature method for the corresponding prop-2-enyl analogues, and 3-carboxy-3-(prop-2-ynyl)pyrrolidine-2,5-dione 7.

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1993, 2549-2553

Synthesis of 3-octyl-, 3-cyclohexylmethyl- and 3-carboxy-3-(prop-2-ynyl)pyrrolidine-2,5-diones required as potential aromatase inhibitors

L. W. L. Woo, H. J. Smith, K. J. Barrell and P. J. Nicholls, J. Chem. Soc., Perkin Trans. 1, 1993, 2549 DOI: 10.1039/P19930002549

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Spotlight

Advertisements